Early bactericides were all inorganic compounds, among them, sulfur powder and copper preparations are still in use today. In 1914, Germany's I. Riem first used organic mercury compounds to control wheat smut, marking the beginning of the development of organic fungicides.
In 1934, W.H. Tisdale and others in the United States discovered the bactericidal properties of dimethyl dithiocarbamate, after which organic bactericides began to develop rapidly. There are three main series of organic sulfur fungicides developed in the 1940s and 50s: thiram, dysen and trichloromethylthio dimethylcarboximide. In addition, organic chlorine, organic mercury, and organic arsenic fungicides have also been developed. . Most of these fungicides are protective agents and have limitations in application.
Since the 1960s, more chemical types of fungicides have appeared, and the most important development is the advent of systemic fungicides. In 1965, Japan developed the organophosphorus fungicide Dabanjing. In 1966, the U.S. developed benomyl, the U.S. developed benomyl in 1967, Japan developed thiophanate in 1969, and the Federal Republic of Germany developed pyraclostrobin in 1974. 1975 Tricyclazole was developed in the United States in 1977, metalaxyl was developed in Switzerland in 1977, and aluminum triethyl phosphate was developed in France in 1978. The systemic agents represented by the above have become the mainstream of the development of fungicides since the 1970s.